Since the development cost of a new drug molecule is very high, efforts are now being made by pharmaceutical companies to focus on the development of new drug dosage forms for existing drugs with improved efficacy and safety together with reduced dosing frequency, and the production of more cost effective dosage forms Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry.1 0 Nil 2 CP10 170 110. 12 137. 3mm to 0. 059 60 0. 5 Nil 2 500 5. 2, 2. Freeze drying of the frozen units, leading to porous Zydis units Sealing of blister packs Packaging of Blister and final product release 15 REVIEW 0F FAST DISSOLVING DOSAGE FORM Hedenstrom, H. Alm, et al. The samples were analyzed at 65 285nm spectrophotometrically. 3 8 500 6. 2. Improved patient compliance 9. It provides rapid swelling and/or good wetting capability to the tablets and thereby a quick disintegration .The disintegrating agents include starch or modified starches, microcrystalline cellulose, alginic acid, cross-linked sodium carboxy methyl cellulose, and cyclodextrin polymers. 3. Key words: Transdermal Drug Delivery System, Transdermal Patches, Anatomy of Skin. FUNDAMENTAL DESIGNING OF FAST DISSOLVING TABLETS (FDT) 5 For rapid dissolution of dosage, water must rapidly penetrate into the tablet matrix to cause quick disintegration & instantaneous dissolution of tablet. 27 60 Table. 43). In vitro dispersion time ? 12 8 0. The formula can contain other ingredients, such as a sweetener. 018 14. Multi tabletpackaging, with dozens of tablets in one bottle. KV Pharmaceutical also claims that the matrix that surrounds and protects the drug powder in microencapsulated particles is more pliable, meaning tablets can be compressed to achieve significant mechanical strength without disrupting taste masking. The tablets had complete disintegration or dissolution in less than 3 minutes. The other methods include rotary shaft method and sieve method. The reason to usepolypeptide components of the same charge was that molecules would repel eachother even after spray drying, so porous and low-bulk-density particles could beformed. In order to produce and control the self-binding properties, this hygroscopic material must have a substantially higher hygroscopicity than that of the carrier carbohydrate (e.g., sucrose). The absorbances of above solutions were measured against Sorensons buffer as blank at 285 nm. 12. 1mm to 3. Suitability for geriatric and pediatric patients, who experience difficulties in swallowing and for the other groups that may experience problems using tablets due to being mentally ill, the developmentally disable and the patients who are un-cooperative, or are on reduced liquid intake plans or are nauseated. The effervescent excipient system aids in rapid disintegration of the tablet, permitting swallowing of pharmaceutical ingredients before they come in contact with the taste bud. 023 18. 5 14 500 5. 64 8 0. It uses an effervescent disintegration pair that releases gas upon contact with water. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc. Metabolism: In humans, the N-oxide is the principal metabolite in the urine; however, this amounts to 1000000 5. Monsanto tablet hardness tester 2. The results revealed that the moderate amount of Gelucire 43/01 and ethyl cellulose provides desired release of ranitidine hydrochloride from a floating system. 8 Bodmeier R, 1999. Many translated example sentences containing "fast-dissolving tablet" - Spanish-English dictionary and search engine for Spanish translations. 1 to about 5% of the capsule. The solvent in the frozen state is removed to produce porous wafers. 5 7 490 3. The bioavailability of some drugs may be increased due to absorption of drug in oral cavity and also due to pre gastric absorption of saliva containing dispersed drugs that pass down into the stomach. The super disintegrants were also found to be compatible with the other excipients of the formulation as well as with drug, which is evident from the drug content values. 52 Table. North American market for Fast-dissolving Tablets is estimated to increase from $ million in 2022 to reach $ million by 2028, at a CAGR of % during the forecast period of 2023 through 2028. Wetting time ? 001). Overall bioavailability. Cost?effective manufacturing processes that utilize conventional, scalable unit operations. A quantity of powder weighing equivalent to 150mg of Ranitidine HCl hydrochloride was taken in 100ml volumetric flask and 0. They are also used in topical and ophthalmic formulations. 3. 27% and 126. Also, metered dose system are less potable while dry powder inhalers cause clogging of device and require skillful operation. However, the tablet press has been designed to make conventional tablets. J App. 13 Reddy LH., Fast dissolving drug delivery system: A review of the literature Indian J.Pharm Sci. 14 Mixing of drug in aqueous solution of carrier matrix materials Filling of suspension (dosing by weight) into pockets of preformed blisters Blister stress passes through freezing tunnel. Do capsules dissolve faster than tablets? Cotton candy process 10 involves formation of matrix of polysaccharides or saccharides by simultaneous action of flash melting and spinning. Angle of repose: 79mg, 95. The temperature sensitivity studies for the prepared formulations at 40C/75% relative humidity for 3 months showed no significant change in in vitro drug release pattern. REFERENCE m and maximum of 3% greater than 250 ? 6,010,719, 2000. 99 39. 013 9. 85 4 0. PHARMACOKINETICS5 In this consideration study has done on absorption, distribution, metabolism and excretion. Partially unionized at salivary pH 14 applied sublimation technology to manufacture tablets that rapidly dissolve in saliva34. These hollow points represent the position of the tablets, and a support is added for each tablet to avoid movement during the disintegration test. Because FDTs are designed to have a quick dissolution/disintegration time, the tablet porosity is usually maximized to ensure fast water absorption into the tablets. JAMA India. hiss and quickly a few times. -cyclodextrin. Several fast dissolving dosage forms are hygroscopic and cannot maintain physical integrity under normal conditions of temperature and humidity. 28 Susijit S., Mishra B., Biswal PK., Omprakash P., Kumar SM,Kumar GJ., Fast dissolving tablet: As A potential Drug Delivery System.2010;(2): 130-133. It then rapidly disintegrates and dissolves to release the medication for oromucosal absorption or with formula modifications will maintain the quick dissolving aspect but allow for gastrointestinal absorption to be achieved when swallowed. Molded tablets shows poor taste masking characteristics. The main aspect of present work was to develop FDT of Domperidone which possesses fast disintegration and high . 020 15. g, 70 ? Superdisintegrants Fast dissolving delivery system comprises low moisture that is convenient for doing, suitable for labeling and easy packing, handling and application. The water soluble drugs may form eutectic mixtures that cannot be frozen adequately to form the rigid structure necessary to support itself after solvent is removed, which may cause collapse of the freeze dried cake. Additionally, several solvents (e.g. 5 kg/cm2 then packed in a well closed air tight container. 09 1 Pass 2 CP-10 4. No significant difference was observed between the desired release profile and batches F2, F3, F6, and F9. Thickness & diameter ? OraSolv technology (Cima Labs) produces tablets by low compression pressure. Single Punch Tablet punching machine 4. The wetting time with saliva preparation was found to be very fast and has the capacity to absorb buffer in the order of CP-10 < BD-10 < CP-5 < BD-5. Water absorption ratio was determined using following equation, Where ? US Patent 5,082, 667. The basic approach in development of FDT is the use of superdisintegrants like cross linked carboxymethylcellulose (croscarmellose), sodium starch glycolate (primogel, explotab), polyvinylpyrollidone (polyplasdone) etc, which provide instantaneous disintegration of tablet after putting on tongue, their by release the drug in saliva. Lavipharm Laboratories Inc. (Lavipharm) has invented an ideal intraoral fast?dissolving drug delivery system, which satisfies the unmet needs of the market. 5cm) containing 6ml of stimulated saliva pH, a tablet was put on the paper, and time for complete wetting was measured. 5 6. I.Pharmaburst Technology Combination with anticholinergics. 02 20 490 1. The matrix formed is partially re-crystallized to have improved flow properties and compressibility. 79 70. g/ml) Cumulative amount of drug release (mg ) % cumulative amount of drug release 1 0. Orodispersible formulations have also been named as orally disintegrating, orodisperse, mouth-dissolving, quick-dissolve, fast-melt and rapid-disintegrating and freeze-dried formulations. 2. Release profile of CP-10 having Crospovidone 10%, prepared by using mannitol (DC), talc, aspartame, flavor was found to have maximum release of 143. Sugars are pleasant tasting and are a good addition to other taste masking methods. None of the individual drug content was out side the limits 90% to 110% (Ref. A plastic material and a water-penetration-enhancer can be the same material. Important ingredients that are used in the formulation of FDTs should allow quick release of the drug, resulting in faster dissolution. Int.J. However, as the tablet disintegrated, the compression distances increased, because the probe had to keep the pressure constant. In order to predict the disintegration time of FDTs and the effects of different formulation parameters, a few methods have been proposed. -cyclodextrin. 24 reported that a combination of super disintegrants i. e sodium starch glycollate- crosscarmellose sodium or sodium starch glycollate- crospovidone were used along with directly compressible mannitol to enhance mouth feel. After swallowing, there should be minimal or no residue in the mouth. Tablets prepared using microcrystalline cellulose; PH-M06 and LHPC in the ratio of 9:1 were very rapidly disintegrating) in saliva. 9 Diameter of periphery(A) 15. The selected tablet formulation, containing 26% galactomannan and 5% crospovidone, disintegrates before the galactomannan starts to swell. FUTURE SCOPE Other cyclodextrins such as 2-hydroxypropyl ? 2. Fast dissolving tablets is one such most advantageous example of the oral drug delivery. Ranitidine HCl is available as tablets. The volatile materials were then removed via sublimation, which generates porous structures. Those highly water-soluble excipients are susceptible to moisture; some will even deliquesce at high humidity. Spray drying Spray drying can produce highly porous and fine powders that dissolve rapidly. 2 (stimulated saliva fluid). These additional, superior benefits allow patients to take their medication anytime and anyplace under all circumstances. 5. Safety 41 Crospovidone is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. g, 80 ? Short-term animal toxicity studies have shown no adverse effects associated with crospovidone however owing to the lack available data acceptability daily in take in human has been specified by the WHO. This essay was written by a fellow student. should be strong enough to survive rough handling during manufacturing and shipping processes, and yet friable enough to instantly dissolve or disintegrate into small particles for easy swallowing by the patient. The trays holding the blister packs are passed through liquid nitrogen freezing tunnel to freeze the drug solution or dispersion. The fast dissolving tablets are formulated by using crospovidone, croscarmellose sodium, SSG and sodium lauryl sulphate as surfactant. Because the water content in the final freeze-dried product is too low for microbes to grow, the Zydis formulation is also self-preserving. 13mg, 92. Most fast dissolving delivery system tablet must include substances to mask the taste of the active ingredient. Swelling: Higher density alkali earth metal salts and water-soluble carbohydrates usually do not provide quick disintegration and a smooth mouth feel. 20 formulated and developed fast dispersible ibuprofen tablets, a direct compression method was used to prepare these two types of tablet containing coated ibuprofen as a high dosed model drug. This approach is especially attractive when working with highly potent or hazardous materials because it avoids manufacturing operations (e.g., granulation, blending, and tableting) that generate large quantities of aerosolized powder and present much higher risk of exposure. I. et al. The tablets show an adequate hardness and fast disintegration and dissolution when put in the mouth20. 02 13 490 1. Jaccard and Leyder et al. Cyclodextrin is also used in cosmetics and food products and is generally regarded as essentially nontoxic and non irritant material; however when administered parenteraly, ? The dry blend was compressed in to tablets in a single punch tablet machine. Microcrystalline cellulose, cross linked carboxy methylcellulose sodium, cross linked polyvinyl pyrrolidone and partially substituted hydroxypropyl cellulose, though water insoluble, absorb water and swell due to capillary action and are considered as effective disintegrants in the preparation of Fast Dissolving Tablets (FDT). Table-16). g, 100 ? These studies indicate that the hydrophobic lipid Gelucire 43/01 can be considered an effective carrier for design of a multiunit floating drug delivery system for highly water soluble drugs such as ranitidine HCl. Ease of administration for patients who are mentally ill, disabled and uncooperative. So, it combines advantage of solid dosage form in terms of stability and liquid dosage form in terms of bioavailability. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. 28 Rapidly dissolving capsules prepared in accordance with the present invention typically contain water-insoluble or sparingly soluble drugs in an amount of about 6 to about 600 mg of the capsule. Tan ? Registered address: Louki Akrita, 23 Bellapais Court, Flat/Office 46 1100, Nicosia, Cyprus The amounts of ranitidine and prokinetic agent can be varied. By accepting, you agree to the updated privacy policy. 8 This porous particle morphology allows for better wicking of liquid into the particle and tablet. g, 40 ? Fast disintegration in the mouth between 5 and 50 seconds, depending on the tablet size. Moreover, the technology utilises a conventional wet granulation process and tablet press for cost-effective production of the tablets with desirable properties. Agilent Ultra Violet Visible Spectrometer 2. Didn't receive the email yet? Popa G et al. Mango flavour(Microlabs,Hosur) ? Each of the three components plays an important role in obtaining tablets with high strength and fast disintegration time. This requires that excipients should have high wettability, and the tablet structure should also have a highly porous network5. g, 50 ? A special peelable backing foil is used to package the Zydis units19. For fast dissolving tablets, lans proprietary Nanocrystal technology can enable formulation and improve compound activity and final product characteristics. Watson RG, Johnston BT et al. Please, take into consideration that VAT tax is totally included in the mentioned prices. Bulk density can be calculated by using following formula: Bulk density = Weight of the powder / Volume of the packing. These tablets disperse in water within 40 seconds and show a crushing strength of 95 N. to develop an orodispersible tablet; a rotatable central composite design was predicted the effects of the quantitative factors mannitol and crospovidone as well as compression force on the characteristics of the 19 tablets. DuraSolv DuraSolv is another Fast Dissolving Technology patented by CIMA labs. Functional category: Tablet disintegrant 7. In vitro testing may not always reflect the real in vivo disintegration of tablets. The future of FDTs lies in the development of FDTs with controlled release properties. Formulation containing crospovidone have lower dispersion time 46- 49sec while formulations with cyclodextrin have dispersion time of 58-62 seconds. Cyclodextrin have been used in the formulation of solutions suppositories and cosmetics. However, ? No water needed 3. (Click on Subscription link in your inbox), Production JobsR&D JobsF&D JobsSales & MarketingQA JobsQCJobsFaculty JobsCRO JobsDRA JobsIPR JobsIT JobsPackaging AlertsHospital Pharmacist, D.Pharm AlertsB.Pharm AlertsB.Sc AlertsM.Pharm AlertsM.Sc AlertsMBA AlertsPharm.D AlertsPh.D AlertsMBBS AlertsMD AlertsMS AlertsWalk-in JobsGovernment Jobs, Privacy Policy | Disclaimer | Terms of Use | Advertise | Sitemap | Send Feedback, RECEIVED AWARD AS BEST PHARMA CAREER PORTAL AT ISFCP, Copyright 2008-2022, PharmaTutor Edu Labs, Pharmacy Infopedia, FAST DISSOLVING TABLETS- A POTENTIAL DRUG DELIVERY SYSTEM. 31 AIM OF THE WORK Ranitidine HCl is a H2-receptor antagonist. 4. Comparative drug release studies with marketed sample 34 MATERIALS AND INSTRUMENTS USED MATERIALS 1. This is reflected by the overall cost of the product. 36 46. 9. 876gm of dibasic sodium phosphate was weighed and dissolved in small quantity of distilled water. 3 Nil 2 500 6. HISTORY Table. A major claim of the some Fast Dissolving Tablets (FDT) increased bioavailability compared to traditional tablets. When tested, The various characteristics of blends to be tested before compression are, Opportunity for Pharmacist to join NPCIL, Department of Atomic Energy, Job for Ph.D, M.Pharm, M.Tech as SRF at Panjab University, Vacancy for Project Associate at Institute of Microbial Technology, Walk in for M.Pharm, B.Pharm, MSc in Production at Alembic Pharma. Oral fast-dissolving tablets, are an examples of a few existing technologieswith the potential to accommodate various physicochemical, pharmacokinetic and pharmacodynamic characteristic of drugs. The key benefits of the Frosta technology are: Taste of Active Ingredients Quick disintegration and dissolution of the dosage form. This sugar disintegrant polymer does not form gels which could retard drug release or result in a gummy texture. Method of preparation of Sorensons buffer pH 6. The increase of tablet hardness with heating and storage did not depend on the crystal state of the lower melting point alcohol.17. Preparation of secondary solution (sodium phosphate solution) 11. The disintegration apparatus consists of a plastic cell partitioned into two parts: one component comprises an inner tank containing a stirring bar, a grid fabricated from stainless-steel, and a disintegration medium (distilled water, 200 m L, 37 2 C); the second component is an outer tank of thermo stated water. 64 g) Drug content uniformity: The drug content uniformity was examined as per I. P specification. After heating, the median pore size of the tablets was increased and tablet hardness was also increased. c. Film-Coated Tablets IN VITRO DISPERSION TIME 44,45 In vitro dispersion time was measured by dropping a tablet in a measuring cylinder containing 6ml of pH 6. 023 18. Moulded tablets posses porous structure, which facilitate easy dissolution. Then the solution was filtered using membrane filter 0. 12 Lailla, J.K., Sharma, A.H., Freeze-drying and its applications, Indian Drugs, 1993; 31:503-513. The purity and potency of the meth depends on the skill of the cooker. D.AdvaTab Technology submit it as your own as it will be considered plagiarism. Tablet hardness1 To archive rapid disintegration, fast dissolve tablets (FDT) are often porous and/or have low hardness and high friability. Apparent bulk density is determined by pouring a weighed quantity of blend into graduated cylinder and measuring the volume and weight. J. Michaelson 17 describe the use of intimate mixture of alginic acid and a water-soluble metal carbonic acid to prepare tablets. To overcome this drug containing spray congealing forms discrete particles. June, 2000; 52-58. Empirical formula : C13H22N4O3SHCl Molecular weight : 350. Wb is weighed of tablet before water absorption. Get original paper in 3 hours and nail the task. Dose lower than 20mg 3. Fast Dissolving Tablets Thesis Ppt: REVIEWS HIRE. 02 69. The similarity factor f2 was applied between the factorial design batches and the theoretical dissolution profile. Because of intimate contacts among all components in the matrix, recrystallization of one component can have significant impact on the characteristics of surrounding components and further change the properties of the matrix as a whole. They were heated at about 93 for 15 min resulted in increased median pore size along with increase in tablet hardness. 05). Two techniques were used in recrystallization. Then, granules were blended with croscarmellose, aspartame, and magnesium stearate and compressed into tablets. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. 10 0. The disintegrated tablet should become a soft paste or liquid suspension, which can provide good mouth feel and smooth swallowing. This can be accomplished predictably and efficiently using Nanocrystal technology. The technology involves incorporation of the drug in water soluble matrix which is then transferred to the perform blister with peel able foil, as the zydis uits are not strong enough to withstand being pushed through the lidding foil of a conventional blister. 24 92. Low moldability saccharides produce tablets with hardness between 0 and 2 kg, when 150 mg of such a saccharide is compressed under pressure of 1050 kg/cm2 using a die 8 mm in diameter. Wet Granulation The tablet was submerged in water and compressed against the bottom of the beaker or petridish with a constant pressure. SELECTION of drug candidate A method of producing a fast dissolving tablet comprising compression-molding a composition comprising an active ingredient, a carbohydrate and a barely sufficient amount of water to moisten the surface of particles of said carbohydrate into a tablet form and a fast dissolving tablet obtainable by the method. The computer enables calculation of the surface area of each tablet at any time point, as well as the design of graphs that show decrease in the tablet surface area as a function of time. Processing techniques such as freeze-drying, molding and sublimation, spray drying, direct compression followed by vacuum drying can be used to formulate ODTs. Just talk to our smart assistant Amy and she'll connect you with the best These are novel dosage forms which will rapidly disintegrate or dissolve in the saliva without the need of water. The taste masking process does not utilize solvents of any kind, and therefore leads to faster and more efficient production. The cheapest estimate is the work that needs to be done in 14 days. 020 15. g. Cotton candy process 32 0. 0288 and 0. These tablets are either very porous or inherently soft molded matrices or tablets compacted at very low compression forces in order to maximize tablet porosity and minimize oral dissolution/disintegration time. 18 Vollmer, Paolo Galfetti. Binders Main role of Binders is to keep the composition of these fast melting tablets together during the compression stage. 5 3 500 5. 21 reported that the prepared lansoprazole fast disintegrating tablets (LFDT) were a patient-friendly formulation that rapidly disintegrated as a basic excipients. Therefore, the demand for developing new technologies has been increasing every year. It complies to USP/BP standand. From the primary stock solution, 1ml was accurately pipetted out and transferred into a 100ml 46 volumetric flask. S. t al. 7 0. to help you write a unique paper. 1) Conventional techniques 3 4 490 4. Porosity and capillary action (Wicking): 33 PLAN OF WORK The present work was carried out to formulate and evaluate rantidine fast dissolving tablets (FDT), using different polymers and super disintegrants in various proportion. OraSolv dosage form have been developed up to 100mg of load and capable of formulate multiple active ingredients in same dosage form. Cyclodextrin should be stored in tightly sealed containers in a cool, dry place. 98 91. m for polyplasdone xl less than polyplasdone xl-10. this guidance provides pharmaceutical manufacturers of new and generic drug products with an agency perspective on the definition of an orally disintegrating tablet (odt)which is a different. 45 CONSTRUCTION OF STANDARD CURVE OF RANITIDINE HYDROCHLORIDE. The third approach is to compress tablets at low pressure and apply various after-treatments to the soft tablets. Lubricants Lubricants remove grittiness and assist in the drug transport mechanism from the mouth down into the stomach.Example: Magnesium stearate, stearic acid,leucine,sodium benzoate, talc, magnesium lauryl sulphate, liquid paraffin etc. In parental formulation, cyclodextrin have been used to produce stable and soluble preparation of drug that would other wise have been formulated using a aqueous solvent. Resend the email. Effervescent Ranitidine HCl tablets 150 and 300 mg, fast-dissolving famotidine tablets 20 mg and capsules of omeprazole 20 mg were administered. -Cyclodextrin (Microlabs,Hosur) 3. Retrieved from https://graduateway.com/fast-dissolving-tablets-of-famotidine/, Stability Studies On Vitamin D Three Tablets Injections, Fast Efficient Motion With Spatial Awareness Parkour, The Adaptation of New Food: Medieval Spices, Crops, Sugar Cane, and Fast Food Analysis. 011 8. AdvaTab technology produces FDT tablets based on a proprietary tablet composition that was designed and patented by Kyowa Hakko Kogyo; in which the lubrication is dispensed onto each tablet by using a spray during the production process. The OraSolv tablet dissolves quickly without chewing or without water and allows for effective taste masking of a wide variety of active drug ingredients, both prescription and non-prescription. Nursing Business and Economics Psychology Management +86. This process is so named as it utilizes a unique spinning mechanism to produce floss-like crystalline structure, which mimic cotton candy. 17 Yoshio K., Masazumi K., Shuichi A., and Hiroaki N.,Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. Ethyl cellulose, methylcellulose, and hydroxypropyl methylcellulose were evaluated as release rate modifiers. Twin-screw high shear extruders blend materials and simultaneously break up particles. 2 Concentration (? This article reviews the importance and unique concept of the fast dissolving tablets with an overview of oral mucosa for drug delivery through it. An internal flow is created by this condition to force the fl owing mass out of the opening provided in the perimeter of a spinning head. 6 6 500 0. The tapping is continued until no further change in volume is noted. 5% (w/w) of non-ground mannitol, 4% (w/w) of crosspovidone, and 0. c 0. 1997, US patent 5595761. 6 11 480 3. Activate your 30 day free trialto unlock unlimited reading. 09 69. 3. 2002, 64: 331-336. INTRODUCTION 96 104. At the same time the rapid hydration rate facilitates an almost immediate softening of the Fast Dissolving Tablet (FDT) upon application in the oral cavity. The typical disintegration time, which is defined as the time at which the film begins to break when brought into contact with water, is only 5 to 10 seconds for the Quick?Dis film with a thickness of 2 mm. AdvaTab can handle high drug loading and coated drug particles. Guyot-Hermann has proposed a particle repulsion theory based on the observation that nonswelling particle also cause disintegration of tablets. One-step granulation processing. Several factors may be considered while selecting an appropriate drug candidate for development of orally disintegrating tablets. 026 21. 3 9 500 6. 5 12 500 5. 9. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. 40 126. Fast-dissolving tablets having analgesic activity was formulated using a 24 combination of superdisintegrants. 2) Patented techniques. FDT were produced by compressing powder containing erythritol (m. pt. Moreover, when the same material is used for making FDTs, the mechanical strength of tablets is increased when porous granules are used. 21 Mattsson. Best Sublingual NMN (Tablets): Alive By Science. Swelling Index = [(Final volume Initial volume)/initial volume)] X 100. 75 62 RESULTS AND DISSCUSSION: The aim of the present work is to prepare Fast Dissolving Tablets (FDT) of Ranitidine HCl. 10 Meyers GL, Battist GE, Fuisz RC. 15 0. 5 12 480 3. Figure5: Scanning electron microscope of FDT (clarithrinTM RediTabsTM). Leaky enteric coats were formulated using a commonly used enteric polymer, Eudragit L 30 D-55, combined with soluble compounds including lactose, PEG 8000 and surfactants (Span 60 (hydrophobic) or Tween 80 (hydrophilic)). 6 Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. In eye drop formulation, cyclodextrin forms water soluble complexes with lipophilic drugs such as corticosteroids. While the claimed increase in 2 bioavailability is disputable, it is clear that the major advantage of these formulations is convenience. 25 used a spray drying technique to prepare fast dissolving tablets. Wide range of doses (up to 200mg of API per unit). prepared rapidly disintegrating tablets using microcrystalline cellulose (Avicel PH-M series) that was spherical and had a very small particle size 7-32 ? Among the two formulations, the formulation prepared by direct compression method using 2%w/w sodium starch glycollate & 1. 24 To achieve this goal, a modified dissolution apparatus was applied to FDTs with disintegration times too fast to distinguish the differences between the tablets when the conventional methods were used. 2. Abstract. The amount of effervescent agent is in general about 2025% of the total weight of the tablet. 4 Allen LV., Wang B., Particulate Support Matrix for making a rapidly dissolving tablet. 4, 5) Batches BD-5 & BD-10 Formulations BD-5 & BD-10 releases the drug 132. The opening of mesh of the sinker was 33.5 mm in height and 3.54 mm in width. Delivery systems dissolve or disintegrate in patients mouth, thus releasing the active ingredients which come in contact with the taste buds and hence, taste masking of the drugs becomes critical to patient compliance. To allow maximal patient acceptability. Sorry, preview is currently unavailable. 17 Koizumi et al. Table. It may be used for shortterm treatment of stomach or small intestinal ulcers. Table . You can download the paper by clicking the button above. Surface active agents Example: sodium doecylsulfate,sodium laurylsulfate, Tweens, Spans,polyoxyethylene stearate. Some cyclodextrin derivatives occur as amorphous powder. The produced tablets are known to have satisfactory physical resistance and disintegrate in the mouth within 1 minute. Fast-dissolving tablets: New dosage convenience for patients. REFERENCES. Fast disintegrating tablets are defined as solid dosage forms containing medicinal substances which disintegrate rapidly usually within seconds when placed upon the tongue. The amount of non direct compression filler is usually about 6095% of the total tablet weight. After the solution or dispersion is filled into blister cavities, it is then frozen in a liquid nitrogen freezing tunnel. Figure 6(A) shows an inner structure of a BenadrylRFastmelt, which used WOWTAB technologyFigure 6(B) shows an inner structure of a Frosta tablet containing vitamin B12 and folic acid. Fast dissolving tablets of Efavirenz (anti HIV agent) were formulated by using combination of microcrystalline cellulose and sodium starch glycolate as super disintegrant. It is necessary to carry out initial studies on a formulation by varying the amount of Pharmaburst from 50 to 80%, depending on the desired mouth feel and disintegration time. A 32 full factorial design was applied to systemically optimize the drug release profile. cite it correctly. Texture Analyzer Method -Cyclodextrin Cavity diameter (A) 6. 54 120. College of Pharmaceutical Sciences, 22 Sunada H, Bi Y. (Ref table-9) d) Wetting time: Wetting time corresponds to the time taken foe the tablet to disintegrate when kept motionless on the tissue paper in a Petri dish. Some of the patients had a good impact on the pharmaceutical market and more improvements are expected in future years, with new drugs to be formulated as fast dissolving dosage formulations. 3 3 490 4. 90 4. 5, 6) From the results obtained, it was observed that drug-CP complexes disintegrate quickly, soluble in water and make drug available for absorption. 27 The availability of the various technologies and manifold benefits of fast dissolving tablets will surely increase its popularity in the near future. Stabilizers for beer, vinegar, fruit and wine, prolonging the storage life. DuraSolv tablets are prepared by using conventional tableting equipment and have good rigidity (friability less that 2%). 0 3 BD-5 170 110. Leaky enteric-coated pellets formulations are defined as entericcoated pellets that allow some of the drug to be released from the formulation in gastric fluid. 024 19. Batch F4 was considered optimum since it contained less Gelucire and was more similar to the theoretically predicted dissolution profile (f2 = 62. 6. Results indicate that rapid disintegration was seen in CP-5 and CP-10 (49 & 46sec. 1 Fast Dissolving Tablets. 65 75. The major drawback of effervescent excipients is their hygroscopicity (i. e. , the ability to absorb atmospheric moisture). Novel technologies with improved performance, patient compliance, and enhanced quality have emerged in the recent past. In any event, the weight ratio of cyclodextrin to acid in rapidly dissolving capsule formulations will be as broadly described hereinabove, but preferably will be from about 1:5 to 5:1, and more preferably from about 3:1 to about 1:1. Th entire freeze drying process is done at nonelevated temperatures to eliminate adverse thermal effects that may affect drug stability during processing.The freeze-drying technique has demonstrated improved absorption and increase in bioavailability, The Frosta tablets are mechanically strong with friability less than 1%, and are relatively stable in an open-air environment. 11. Table No. For the patients who have a problem in swallowing, mainly the children and the old, oral disintegrating tablets (ODT) is a good choice. After omeprazole, pH 3 was never reached. 11. Smooth mouth feel. Zinc is a chemical element with the symbol Zn and atomic number 30. 3. Table. Therefore, it was presumed that crosspovidone acted as a grinding assistant for D- mannitol in the cogrinding process, enhancing the hardness of tablets by increasing the contact area among powder particles. 10 5. 5. CYCLODEXTRINS36 1. g/ml) Cumulative amount of drug release (mg ) % cumulative amount of drug release 1 0. 6 14 510 2. 44 8 0. The drug released from orodispersible formulations is absorbed through pregastric (oral cavity, pharynx, and esophagus), and gastric segments. A theoretical dissolution profile was generated using pharmacokinetic parameters of ranitidine hydrochloride. Abdelbary. In vitro determination of disintegration time of quick-dissolve tablets using a new method. Price: Because of the soft and fragile nature of OraSolv tablets, a special packaging system, known as PakSolv, was developed to protect the tablets from breaking during transport and storage. 11 described a method of producing a fast dissolving tablet using water as a pore forming material. 13 Batch code CP-10 Tablet no Weight of individual tablet(mg) Average(mg) %deviation No. DEFINITION The therapeutic effect of drugs inhibiting acid production on acid-related discomforts is related to both the onset and duration of action of the drug. Fast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, Oro dispersible tablets, rapimelts, porous tablets, quick dissolving etc. with saliva, resulting in solution or suspension of the administered medicine also commonly known as fast melt, quick melt, orally disintegrating tablets, and orodispersible systems. A hygroscopic material such as xylitol must be present in the system to provide good self-binding characteristics to the final matrices. 76 61. Aspartame(Microlabs,Hosur) ? (adsbygoogle = window.adsbygoogle || []).push({}); ABOUT AUTHORS: A pleasant taste inside the mouth becomes critical for patient acceptance. The carrier materials include saccharides, polysaccharides, and mixtures thereof. No. Tablets with high porosity show poor disintegration due to lack of adequate swelling force. Oral route having the highest patient compliance is regarded as the most convenient,safest and also the most economical method of drug delivery. Preparation of fast dissolving tablets by direct compression method. 650 ml of Sorensons buffer solution (pH 6. There are four major mechanisms for tablets disintegration as follows: Batches CP-5 & CP-10 Formulations CP-5 & CP-10 releases 138. Microcrystalline cellulose and low substituted hydroxypropylcellulose were used as disintegrating agents in the range of 8:2 9. to prepare fast dissolving tablet. The lubricant blending time scan also be increased to 1025 minutes or longer. writing your own paper, but remember to 6 5. Evaluation of fast dissolving tablets (FDT) for the following physiochemical parameters. Fast dissolving tablets have received ever increasing demand during the last decade and the field has become a rapidly growing area in the Pharmaceutical industry. Requires no water intake. 9). There are no products using the OraQuick technology currently on the market, but KV Pharmaceutical has products in development such as analgesics, scheduled drugs, cough and cold, psychotropics, and anti?infectives, K.Quick Dis technology Collapse protectant such as glycine prevents the shrinkage of units. Co-drying of mannitol and microcrystalline cellulose leads to the formation of excipients granulates with superior properties compared to physical mixtures of components or with individual components. Research Scholar, Department of Pharmaceutics, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, India, DOI: The ultimate characteristics of a drugfor dissolution in mouth and pre gastric absorption from fastdissolving tablets include: Disintegration time was determined at the point at which the tablet disintegrated and passed through the screen of the sinker completely. They are also highly water soluble and dissolve quickly in saliva. After freeze-drying the aluminum foil backing is applied on a blister-sealing machine. Dose lower than 20mg The sustained input results from the combined effects of the formulation and GI transit effects on pellets. Fast dissolving drug delivery system can be obtained by the various techniques i.e. Skin is a good medium from that absorption of the drug takes place. 31 Disintegrant addition technique is one popular techniques for formulating Fast-dissolving tablets . INVITRO DISPERSION TIME In vitro dispersion was absorbed in the range of 46-62 seconds for all the formulations. 10 Intragastric pH after oral administration of single doses of Ranitidine HCl effervescent tablets, omeprazole capsules and famotidine fast-dissolving tablets to fasting healthy volunteers. Fast dissolving tablets establish an innovative dosage form which overcomes the difficulties of swallowing and geriatric populations The clinical studies show FDTs can improve patient compliance, provide a rapid onset of action, and increase bioavailability. Examples of sugar-coated tablets include Reasulf tablets - dried ferrous sulphate BP 200mg (Reagan Remedies Ltd.), Advil - Ibuprofen tablet BP 200mg (Pfizer Consumer Healthcare) Ebu-200 - Ibuprofen tablet BP 200mg (Me cure Industries Ltd) etc. 3.2. -dextrin; cavamax W7 Pharma; cycloheptaamylose kleptose; 3. http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).727-36, All 2023 are reserved by International Journal of Pharmaceutical Sciences and Research, This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, Submit your manuscript at https://ijpsr.com/manuscript-submission/, Subscribe to YouTube Channel of SPSR Patented Technologies4,9 1. First, nano particles were formed by mechanical grinding, precipitation, or any other suitable size reduction process. 14 44 10. cyclodextrin is soluble 1 in 200 parts of propylene glycol, 1 in 50 parts of water at 20c, 1in 20 at 50c, practically insoluble in acetone, ethanol and methylene chloride. Hence, their manufacture requires control of humidity conditions and protection of the final product. Predictions of plasma concentrationtime profiles of the model drug ranitidine hydrochloride from leaky enteric-coated pellets in fasted conditions and from immediate-release formulations were performed using computer simulations. 1 Approaches have been taken to mask the unpleasant taste of drugs Sensory approaches Using flavoring and sweetening agents nhibiting bitterness Numbing of taste buds Complexation & adsorption Complexation with ion-exchange resins Formation of inclusion complexes with ?-Cyclodextrin derivatives Adsorption of drugs onto clays or other adsorbents Wax embedding of drugs Chemical approaches Formation of prodrugs Formation of different salts Barrier approaches Using viscosity modifiers Using Emulsions Using Liposomes Using Microspheres 3. The manufacture process can be carried out under normal temperature and humanity conditions. FUTURE POTENTIAL Mannitol is used as a matrix former, and camphor was used as a sublimating agent. Examples include Gyno-Tiocosid (Neimeth), Gynesatum- Clotrimazole vaginal Tablet (Chazmax Pharmaceutical Industries Limited), Nystamark-Nystatin Vaginal Tablet (Mark Pharmaceuticals) etc. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. Stabilizers for moisture sensitive active ingredients(e. G. Vitamins, enzymes). Tablets obtained by the conventional compression method are less friable, but disintegrate more slowly.6 The compression Table 1 Examples of fast dissolving tablets currently available on the market Drug product Active ingredient Indication Marketing company Technology Technology Company Alavert Loratadine Allergy Wyeth OraSolv/DuraSolv Cima Lab The therapeutic effect of drugs inhibiting acid production on acid-related discomforts is related to both the onset and duration of action of the drug. Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. 01 3. Thereafter pH increased steadily, reaching pH 4 after 20-40 min and pH 6 after about 70 min. The bioavailability of some drugs may be increased due to absorption of drug in oral cavity and also due to pre gastric absorption of saliva containing dispersed drugs that pass down into the stomach. 2 Acidity/alkalinity pH=5. The film is placed on the top or the floor of the tongue. The mean percentage of Ranitidine hydrochloride released at various time intervals was calculated and plotted against time. Pharma Tech, 2003; 35: 7-9. Pharmacokinetics Absorption: Ranitidine HCl is 50% absorbed after oral administration, compared to an intravenous (IV) injection with mean peak levels of 440 to 545 ng/mL occurring 2 to 3 hours after a 150-mg dose. In this process, the feedstock is subjected to centrifugal force and to a temperature gradient simultaneously. It enhances flavor systems and can be used to mask 7 some unpleasant bitter taste characteristics the approximate sweetening power is 180- 200 times that of sucrose. 3, P < 0. Transdermal drug delivery systems (TDDS) permit delivery of contained drug into the circulation via permeation through skin layers at a controlled rate. Chem Pharm Bull 2006, 54(1): 99-102. Friability test ? It appears that you have an ad-blocker running. 4 4. 3 11 510 8. g, 90 ? 07 59. It was reported that the formulation containing 6% croscarmellose sodium was found to give best results and the tablets exhibited higher rate of release. Table. Because the units are fragile and light-weight, they cannot withstand the pressure of being pushed through the foil of a conventional blister. 75 vs. 2. Mechanism of Superdisintegrants8 30 To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets (ODT), has emerged as alternative oral dosage forms. A tablet was adhered to the bottom of a probe, which was attached to the load cell with a very thin layer of glue or double-sided tape. Researchers have formulated ODT for various categories of drugs used for therapy in which rapid peak plasma concentration is required to achieve the desired pharmacological response.6 These include neuroleptics, cardiovascular agents, analgesics, anti allergic, anti-epileptics, anxiolytics, sedatives, hypnotics, diuretics, anti-parkinsonism agents, anti-bacterial agents and drugs used for erectile dysfunction. An agent can be an active pharmaceutical agent or a non-pharmacological agent, which is needed to be delivered by means of a fast dissolving delivery system. The variables studied were sodium bicarbonate (X1), citric acid (X2), and superdisintegrant, Ac-Di-Sol (X3). Mannitol or sorbitol may be added to impart crystallinity and hardness. 016 12. ? This includes both the pharmacologically active ingredients (drug) and the excipients (additives). 7. Strong mechanical property with friability less than 1%; and Detoxicants in detoxifiers or toxin absorbents. A method of producing a fast-melt tablet comprises the steps of forming a mixture of components, the mixture comprising at least one fast dissolving sugar alcohol, at least one disintegrant or osmotic agent, and at least one an active component, blending the mixture for a period of time, and directly compressing the blended mixture at a compression force of typically between 5 and 20kN to form . The other was using crystallization modifiers, which were included in floss ingredients at 0.0120.0% the weight of the floss. urea, ammonium carbonate, ammonium bicarbonate, hexamethelene tetramine, camphor etc.) Schermeier. 36 6 0. Time(min) Absorbance concentration (? T. et al. Rapid release 8. -and ? FIGURE2:SCHEMATIC DIAGRAM OF BUCCAL MUCOSA. 02 3. The formulated microspheres were free flowing with good packability and encapsulation efficiencies were up to 96%. 52 The purpose of this research was to develop and optimize a controlled-release multiunit floating system of a highly water soluble drug, ranitidine HCl, using Compritol, Gelucire 50/13, and Gelucire 43/01 as lipid carriers. Tagarro. 754g/cm3 Melting point 255-265c Moisture content 13. The percentage of deviation of individual tablet weights from the average tablet weight was found to be with in the I. P limits 7. V. S. Mastiholimath, P. M. Dandagi et al. 5 19 480 1. Drug micro granules may be prepared by using the conventional techniques like coacervation, microencapsulation, extrusion-spheronization or simple pan coating method. As a result, there can be a high level of tablet breakage unless special packaging systems are used. 60 2 0. 14 Debjit B., Chiranjib B., Krishnakanth R., Pankaj, Margret C.,Fast Dissolving Tablet: An Overview Journal of Chemical and Pharmaceutical Research, 2009, 1(1): 163-177. Abdelbary described a new approach of preparing FDTs with sufficient mechanical strength, involving the use of a hydrophilic waxy binder (Superpolystate, PEG-6-stearate) by melt granulation or wet granulation. Solid Pharmaceutical dosage in tablet triturates form and method of producing the same. 02 17 490 1. 2. Description Cyclodextrin occurs as white, practically odorless, fine crystalline powder, having slightly sweet taste. Functional category Solubilizing agent, stabilizing agent. Freeze drying or Lyophilization20 A process in which water is sublimated from the product after freezing. Supplemental understanding of the topic including revealing main issues described in the particular theme; of tablets showing % deviation more than allowed 1 500 497 0. Active ingredients can be microencapsulated or nano encapsulatedto further achieve taste masking.This formulation technique gives porous powder and disintegration time < 20 seconds. In vitro dissolution time ? 6 Nil 2 490 1. 51 81. Side effects of NMN supplements. A fast dissolving tablet produced by Kuno et al., 2005 contained erythritol (MP: 122) and xylitol (MP: 93-95). These are novel types of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. Dry Granulation Unlike some other intense sweeteners, aspartame is metabolized in the body and consequently has some nutritive value. The tax will be charged only from EU customers. Short half life and frequent dosing. 10 Intragastric pH after oral administration of single doses of Ranitidine HCl effervescent tablets, omeprazole capsules and famotidine fast-dissolving tablets to fasting healthy volunteers. 13. As a result, the tablets are hard and durable yet do not impede liquid entry upon contact with saliva. 5 6 490 3. Product differentiation based upon a combination of proprietary and patent?protected technology elements. Check the source www.HelpWriting.net This site is really helped me out gave me relief from headaches. 66 54. It was in the range 450 510mg (Ref table-11). 0-45. numerous styles of transcutaneous patches are used to incorporate the active ingredients into the circulation system via skin. Synonym ?-cycloamylose; dextrinsloamylose; ? 54 121. AA, Rhodes CT, et al. 047 50 0. 5 13 500 0. As heat and water are not involved, this is one of the major advantages of direct compression. 4 3 500 0. -cyclodextrin C56H98O35 = 1135 5. 05 3. So it will not only act as a binder but also increases the physical resistance of tablet and will also helps in the disintegration of the tablets as it melts in the mouth and solubulises rapidly leaving no residues. CONTENT 15. 38 4 0. It is these pores that increase the absorption of water by capillary force. The height of the funnel is adjusted in such a way that the tip of the funnel just touches the apex of the heap of blend. To increase mechanical strength sucrose, acacia or polyvinyl pyrollidone are added. Garima Yadav*, Anupriya Kapoor and Shilpi Bhargava, Authors Address: 0-6. 024 19. Fast dissolving tablet (FDT) is really a new dosage form which may be disintegrated. 4 18 510 2. Reaction Filtration Chemistry. 1N NaOH. Then the amount of the drug was calculated using standard graph. Procedure 40 100mg ranitidine HCl was accurately was weighed and dissolved in a small portion of NaOH in a volumetric flask and then the volume was made up to 100ml Sorensons phosphate buffer(pH 6. By continuing well Small to moderate molecular weight A typical procedure involved in the manufacturing of ODT using this technique is mentioned here. In IIR Conference on Drug Delivery Systems,October, 1998. After omeprazole, pH 3 was never reached. 15 Batch code BD-10 Tablet no Weight of individual tablet(mg) Average(mg) %deviation No. a) Hardness: The prepared tablets in all formulations possess good mechanical strength with sufficient hardness. The drug should be chemically stable and water insoluble, with a particle size smaller than 50 m. 15 using carboxymethyl cellulose as disintegrating agent and one swelling agent consisting of modified starch or microcrystalline cellulose formulated rapidly disintegrable multi particular tablets. These systems ar simple to use and take away as and once desired. All the processing utilized the conventional tableting technology and the tablets produced are reported to have good mechanical strength and disintegration time less than one minute. Pharm. 2. 54 61 COMPARATIVE DRUG RELEASE STUDIES OF THE PREPARED FAST DISSOLVING TABLETS WITH COMMERCIALLY AVAILABLE RANITIDINE HCL TABLETS To compare drug release studies of the prepared fast dissolving tablets with commercially available Zinetac tablets was selected as a choice and carried out dissolution studies. They disintegrate instantaneously releasing the drug which dissolve or disperses in the saliva.According to European pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. 23 Sugimoto M, Matsubara K, Koida Y, Kobayashi M. The preparation of rapidly disintegrating tablets in the mouth. 5 13 500 5. -cyclodextrins, have been the subject of extensive toxicological studies. Immediately after the last noticeable granule has disintegrated, the stopwatch is stopped and the time recorded. 22 prepared rapidly disintegrating tablet (RDT) and reported the problem of certain RDT as low physical resistance and highly friability. g/ml) Cumulative amount of drug release (mg ) % cumulative amount of drug release 1 0. The taste-masking technology should also be compatible with FDT formulations. Processing techniques such as freeze-drying, molding and sublimation, spray drying, direct compression followed by vacuum drying can be used to formulate ODTs. The time for the tablet to disintegrate was determined by measuring the distance the probe traveled into the tablet. They are also highly water soluble and dissolve quickly in saliva. A 32 full factorial design was used for optimization by taking the amounts of Gelucire 43/01 (X1) and ethyl cellulose (X2) as independent variables, and the percentage drug released in 1(Q1), 5(Q5), and 10 (Q10) hours as dependent variables. This phenomenon also resulted in partial taste masking of unacceptable taste of the drug. The 47. 28 Shah NH et al. Wateruptake by tablet depends upon hydrophilicity of the drug /excipient and on tableting conditions.For these types of disintegrants maintenance of porous structure and low interfacial tension towards aqueous fluid is necessary which helps in disintegration by creating a hydrophilic network around the drug particle. DESIRABLE CHARACTERISTICS OF FAST DISSOLVING TABLETS4. m in size for kollidon CL minimum of 90% of particles are below 15 ? Typical Properties Table. WATER ABSORPTION RATIO 42 A piece of tissue paper was placed in small Petri dish containing 6ml of water. Safety Cyclodextrins are starch derivatives and are mainly used in oral and parental formulations. Rate of absorption from the saliva solution. For the last few years, there has been an enhanced demand for more patient friendly dosage forms. 29 An attempt was made for preparation of fast dissolving tablets of a model bronchodilator, salbutamol sulphate with an aim of 22 educing the lag time and providing faster onset of action to relieve immediately acute asthmatic attack. 21 Wilson CG, Washington N, Peach J, Murray GR, Kennerley J. Th e behaviour of a fast-dissolving dosage form (Expidet) followed by gamma-scintigraphy. 1Final Year B.Pharm student Batch F9 showed the highest f2 (f2=75) among all the batches, and this similarity is also reflected in t50 ( 214 minutes) and t80 ( 537 minutes) values. g/ml) Cumulative amount of drug release (mg ) % cumulative amount of drug release 1 0.
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